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Would you like exposure to state-of-the-art technologies in cancer care while integrating computational analytics? We have a unique opportunity to work with an interdisciplinary team bridging the Harvard Medical School, the Massachusetts General Hospital, and the Broad Institute of Harvard and MIT in the Rheinbay and Lawrence Groups at Massachusetts General Hospital Cancer Center. We are seeking well-qualified candidates to join our team of computational biologists working at the forefront of cancer research and treatment. We use computation as a powerful microscope to study both the fundamental biology of cancer initiation and progression, as well the diagnosis and treatment of cancer patients in the hospital setting.
The successful candidate will be joining a collaborative team studying somatic mutations accumulated during therapy exposure, and how patterns of such mutations can introduce vulnerabilities for drug development. Other responsibilities will include method development and analysis for state-of-the-art liquid biopsy technologies to monitor therapy response during treatment and analysis of 'omics' data from different cancer types.
Qualifications Principal Duties:
Apply existing and novel algorithms to cancer data sets, analyze data quality, critically review and analyze results, communicate results to biologists, computational biologists, software engineers and clinicians.
Work with Cancer Center researchers to understand experimental procedures and the kinds of data produced (e.g. DNA sequencing, RNA sequencing, epigenetic readouts, clinical outcome annotations). Meet and discuss with clinical and experimental colleagues to identify analytical challenges and goals.
Explore novel data visualization tools, with emphasis on integrating diverse data types and extracting clinically relevant insights.
Contribute to scientific writing and creation of data figures to be included in research publications
Required Skills & Qualifications:
- B.A/B.S. in one of Computational Biology, Bioinformatics, Biology, Computer Science, Mathematics, Physics, or a related quantitative discipline.
- Independent, self-motivated drive to push research forward.
- Excellent programming skills (using any of R, Matlab, Java, Python, Perl, C, etc.)
- Nimble approach to programming and data analysis, with an emphasis on simple, intuitive, reasoning: quickly open unfamiliar datasets, generate simple visualizations to project the data onto our brains as usefully as possible, to stimulate hypothesis generation and the next steps of the analysis.
- Comfort using Word, Excel, Powerpoint or Google Suite tools to communicate results between team members.
- Ability to work together with multi-disciplinary teams comprising physicians, biologists, statisticians, and software engineers.
- Strong organizational and record-keeping skills
- Fluency in spoken and written English
About the employer
Massachusetts General Hospital (MGH), consistently rated among the top three hospitals in the nation by U. S. News and World Report, is located in the heart of Boston, Massachusetts. The Center for Cancer Research (CCR) is the engine for discovery for the MGH Cancer Center. Working together, the CCR science faculty and the Hospital's renowned clinical staff are recognized worldwide as pioneers in the new field of "personalized medicine", based on the realization that every human tumor has unique characteristics, and that understanding those characteristics can provide vital information about disease progression and help predict the success or failure of today's therapies. Researchers in the CCR are also deeply involved in the creation and development of "smart drugs" that target specific disease pathways to produce new, more effective anti-cancer drugs, potentially with fewer side effects.
EEO Statement Massachusetts GeneralHospital is an Equal Opportunity Employer. By embracing diverse skills, perspectives and ideas, wechoose to lead. Applications from protected veterans and individuals withdisabilities are strongly encouraged.Partner's Healthcare is acting as an Employment Agency in relation to this vacancy.
MGH Institute of Health Professions, founded by Massachusetts General Hospital in 1977, is an innovative and independent graduate school in Boston that is a member of Partners HealthCare. A progressive leader in developing comprehensive models of health care education, the MGH Institute prepares advanced practice professionals in the fields of nursing, physical therapy, occupational therapy and communication sciences and disorders through a distinctive combination of academic study, clinical practice, and research. More than 1,200 students are enrolled in graduate level and certificate programs, with an increasing number of courses available online. The Institute is accredited by the New England Association of Schools and Colleges (NEASC).
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